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Adverse reactions next advice approximately adverse reactions has been obtained in clinical trials conducted with the help of Upjohn and including 1712 patients treated with Caverject. The most general adverse reactions after injection of Caverject within cavernous is a affliction in the penis. In most cases, penile affliction was regarded as gentle or change. Alone three percent of patients discontinued the medicine as of affliction in the penis. Hematoma at the injection point, probably associated with the method of injection, however not with the activity of alprostadil, is seen in 3% of patients. The frequency of prolonged erection defined as an erection that lasts 4 to 6 hours was 2%. The frequency of priapism defined as an erection fast 6 hours or added was 0.5%. In most cases, there was an independent relaxation of the penis. Hemodynamic changes, manifested lower blood force and increased passion percentage were observed in clinical trials, mostly at doses of Caverject 20 and 30 micrograms, respectively, and, apparently, were dose dependent. But, these changes accomplish not normally accept clinical significance, alone 3 patients 0.2% treatment was discontinued as of symptomatic hypotension. Less general are fibrosis, oedema of the penis, reckless on the penis, balanitis, injection point haemorrhage, inflammation, itching and swelling of the injection point, bleeding from the urethra, activity the heat in the penis, numbness, a fungal infection, irritation, sensitivity, phimosis, prurigo, erythema, venous discharge, painful erection, and ejaculation disorder. You should again understand the systemic reactions of the drug before you acquire Caverject. Seldom affliction in the testicles, testicular swelling, scrotal affliction and tension, increased urination, incontinence, imaginable fluctuations in blood force, supraventricular extrasystoles, peripheral vascular disorders, dizziness, headache, hyperesthesia, weakness in the buttock, localized affliction in the buttocks, the legs, genitals, belly, pelvic affliction, lower back, flu-like syndrome. Overdose is accepted that after a man has vnutrikavernoznogo government of vasoactive substances, including alprostadil, there may be prolonged erection andor priapism. Treatment of priapism can comprehend a array of approaches, including aspiration, vnutrikavernoznoe introduction of sympathomimetic amines or surgical treatment. The patient should be warned that he should report to your doctor approximately the cases of prolonged erection, continued 600 or added. Drug Interactions With simultaneous treatment with anticoagulants heparin, warfarin increases the risk of bleeding. 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